According to the MIT Technology Review website on the 19th, Harvard University's materials scientist and bioengineering professor Jennifer Lewis's laboratory uses 3D printing technology to create the proximal tubules in the human kidney, which is the most basic unit of the kidney. An important structure that functions almost identically to the proximal tubules in healthy kidneys. New artificial tissue can be used to help patients with impaired kidney function in vitro, as well as to test new drug toxicity in drug development, an important step toward obtaining a portable artificial kidney.

Researchers have been trying to make artificial kidneys, but over the past 20 years, they have been unable to overcome the enormous challenges of the complex three-dimensional structure and internal honeycomb structure of the human kidney. The proximal tubule is the longest and thickest segment of the renal tubule, and is the "reabsorption" site of almost all glucose, amino acids and proteins in the original urine and most of the water, ions and urea.

The new artificial proximal tubule tissue was created by Louis Labs using their innovative bioprinting technology developed in the early days. Bioprinting technology utilizes a variety of different gel-like "inks". After printing, the ink is removed, leaving a hollow tube, and then adding cells to the empty tube to develop the desired tissue. This technology can be used to print complex structures in different tissues of the human body, including vascular systems that maintain tissue activity.

Harvard medical scientists have discovered that 3D printed kidneys are close to real features

The world's population suffering from chronic kidney disease is as high as 10%, and millions of patients need to rely on dialysis to maintain their lives. However, dialysis machines cannot replace the kidneys after all, and often make patients very painful. They hope to relieve the pain through kidney transplants, but due to a shortage of kidneys, only 16,000 people are lucky enough to receive kidney transplants every year. Louis said that with artificial proximal tubules, the entire kidney can theoretically be synthesized, and perhaps in a few years, 3D printed kidneys can be transplanted for patients.

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