Release date: 2016-03-11

According to a report by the CBS News Network on March 9, the Cleveland Hospital of the United States issued a statement on the 9th that the first uterine transplant surgery in the United States failed. Due to complications in the female patients undergoing transplantation, the doctor has urgently performed the operation. , removed the transplanted uterus.

The Cleveland Hospital statement stated: "We have been very sad to announce that the patient Lindsey has had a sudden complication, and the doctor had to urgently remove the newly transplanted uterus."

Cleveland Hospital performed a uterine transplant on 26-year-old Lin Xi on February 25, and the entire operation lasted 9 hours. The transplant medical team held a press conference on the 7th, when Lin Xi also appeared happy together.

Clinical Trials

Cleveland Hospital announced in November 2015 that it will carry out uterine transplants for 10 women with Uterine Factor Infertility (UFI) in the future. According to statistics, about 3% to 5% of women worldwide suffer from uterine infertility, which is an irreversible disease. The main causes of female infertility due to the disease include congenital uterine loss, uterine ablation, and uterine dysplasia leading to functional loss.

At the beginning of the clinical trial announcement, Cleveland Obstetrics and Gynecology Chairman Tommaso Falcone said that there are currently very few options available for women with uterine infertility. Although some ways can help these women become mothers, such as surrogacy. However, often these pathways are accompanied by ethics, social, cultural, legal and other related social disputes.

Long “pregnancy” road

For patients with uterine infertility, organ transplantation is only the first step in the long road of "pregnancy." The mature egg of the patient needs to be fertilized prior to uterine transplantation and frozen for later transplantation. In addition, according to the Cleveland Clinic report, patients will also undergo key steps:

-- Over 12 months of complete healing of the transplanted uterus

-- One year after uterine transplantation, the frozen embryo is thawed and implanted. Only one fertilized egg can be implanted in a single time until the patient successfully "pregnant"

- Always take anti-rejection drugs during pregnancy

- The entire pregnancy and survival process must be monitored by the obstetric team for risk monitoring

- Every month, a cervical biopsy is needed to determine if the transplanted organ is repellent

-- need cesarean section surgery

-- After having 1 or 2 children, the transplanted hysterectomy needs to be removed by hysterectomy (the anti-rejection drug will no longer be needed)

Sweden is the world leader

Although for the United States, this uterine transplant is the first time. However, the team of doctors at the University of Gothenburg in Sweden has successfully completed 9 uterine transplants. Among them, 5 patients were successfully conceived and 4 were successful.

The main investor in the discipline at Cleveland Hospital said, “Successful Swedish experience shows that healthy uterus transplants can produce healthy offspring.”

Source: Global Health

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