Scientists develop more accurate prognostic evaluation strategies for prostate cancer

August 04, 2016 Source: Bio Valley

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Recently, researchers from the University of Cambridge and other departments published an article in the international journal PLoS Medicine that male patients diagnosed with prostate cancer should be accurately estimated for the risk of prostate cancer death and appropriate treatment for the treatment of the disease.

Prostate cancer is one of the most common cancers affecting men's health. When the lesion is mainly concentrated on the prostate, the patient will be diagnosed with prostate cancer, and there is a great variability in the risk of progression and death of the disease, thus providing an accurate The method to assess the risk of death from prostate cancer in an individual is important for developing a reasonable treatment, and the appropriate treatment for the patient includes from surgery to regular observation management, and patients should be given some advice and support.

Based on an analysis of data from more than 10,000 male patients with prostate cancer in the UK, Gnanapragasam and colleagues developed a novel strategy in which researchers use simple, universal clinical measures such as prostate-specific antigens. Factors such as (PSA) level, disease stage, and tumor grade were divided into five levels with different levels of prostate cancer death risk; the researchers analyzed the two major prostate cancer groups separately, and the results showed that compared with the current majority For a level 3 risk stratification system in nationally and internationally recognized guidelines, this new strategy can better predict the risk of death from prostate cancer in individuals.

The investigators noted that because the study was limited to cancer registry records and a relatively short follow-up duration (median 6.9 years), additional independent cohort studies were needed in the future to further confirm this. Finally, in a dissertation, the researcher Sigrid V. Carlsson et al. discussed the importance of accurate risk assessment of prostate cancer for decision-making guidance for doctors and patients.

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