Recently, Ascentage Pharma (hereinafter referred to as "Yasheng") and UNITY Biotechnology (hereinafter referred to as "UNITY") announced that they have jointly collaborated globally on the development of a new anti-aging therapeutic drug "Senolytic Therapies" based on the elimination of aging cells.
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The Yasheng Pharmaceutical team has been engaged in the research and development of small molecular targeted drugs for programmed cell death for more than 10 years. It has established a "best-in-class" antitumor drug compound library and a targeted antitumor lead compound in the clinical stage.
UNITY Biotechnology has been working on the discovery of cell aging and aging for up to four years with the support of ARCH Venture Partners, Venrock, and Seng Cheng Capital, and demonstrated in animal models the removal of aging cells to prevent or reverse many Outcomes of age-related diseases include osteoarthritis, atherosclerosis, glaucoma, and kidney disease. In February of this year, UNITY co-founder and molecular biologist Jan Van Deursen of the Mayo Clinic published a new study in Nature magazine. The UNITY research drug cleared the aging cells in mice and averaged them. Life is extended by about 25 to 35%.
"At UNITY, we have confirmed that aging is the main cause of aging and age-related diseases," said Dr. Nathaniel David, founder and CEO of UNITY. "We evaluated a large number of drug candidates that can eliminate aging cells. Sheng Medicine's compounds stand out from the crowd. This collaboration has allowed us to use Ya Sheng's compound library to greatly accelerate the progress of drug development, and to delay the aging effects by containing or reversing some of the diseases related to aging."
Yasheng Pharmaceutical's R&D team has maintained outstanding results in the design of structure-based drugs and the optimization of small molecule targeted drug targets acting on protein-protein interactions. "We chose Yasun Pharmaceutical as a partner in the field of anti-aging, not only because of its cutting-edge technology, but also because of the layout of the global market."
As part of the cooperation agreement, the two companies plan to set up a joint venture company in China to specialize in the development and commercial promotion of Senolytic Therapies in China.