Oncogene knockout can completely inhibit lung cancer August 3, 2018 Source: Science and Technology Daily Lung cancer is the devil with the highest mortality rate among all tumors. A few days ago, good news came from the Kunming Institute of Zoology of the Chinese Academy of Sciences. The Institute of Cancer Stem Cell Biology has successfully revealed the mechanism by which oncogenes maintain lung cancer. The results have been published online in the international journal Treatment Diagnostics. According to reports, HUWE1 gene is a ubiquitinated ligase, which can control a large number of biological processes closely related to tumorigenesis, such as DNA damage repair, cell proliferation, apoptosis, by regulating the stability of the substrate. Differentiation and cell homeostasis. A large body of literature indicates that HUWE1 is overexpressed in lung cancer, and overexpression of HUWE1 may lead to a worse prognosis, which means that HUWE1 has an oncogene function in lung cancer. In order to study the mechanism of action of HUWE1 in lung cancer, Zhao Xudong's research group used gene manipulation technology to knock out it in lung adenocarcinoma cell lines, and found that HUWE1 deletion significantly inhibited tumor cell proliferation, colony formation and tumorigenic ability. The main substrate expression after HUWE1 knockout was detected, and the change of human tumor suppressor gene P53 was found to be the most significant. Further studies have shown that HUWE1 knockout leads to the accumulation of human tumor suppressor gene P53, which can inhibit tumorigenesis. This not only inhibits the cell cycle-controlling complex activity, but also blocks lung cancer cells, and also down-regulates hypoxia-inducible factors and prevents tumor angiogenesis. To further clarify the role of this oncogene, they constructed a mouse lung cancer model using genetically engineered mice and found that this oncogene knockout completely inhibited the development of lung cancer. The results demonstrate that the oncogene HUWE1 plays an essential role in the development of lung cancer. In addition, the oncogene MDM2 is also considered to be the major ligase that marks the P53 human tumor suppressor gene and promotes its degradation; it has been shown that a large number of small molecule compounds that inhibit the activity of oncogenes and activate P53 have significant anti-tumor activity. By analyzing lung cancer data, the researchers found that the differential expression of MDM2 in lung cancer and adjacent tissues was far less than that of HUWE1, and the survival curve showed that the expression of MDM2 was not directly related to the prognosis of patients. Therefore, HUWE1 may be more suitable as a therapeutic target than MDM2 in lung cancer. (Zhao Hanbin) Tetanus Shot,Tetanus Vaccine,Hepatitis B Injection,Hep B Vaccine FOSHAN PHARMA CO., LTD. , https://www.foshanmedicine.com