In December 2017, Beijing Fruit Shell Biotechnology Co., Ltd. (hereinafter referred to as: Shell Bio) cooperated with international genetic testing company giant Illumina to develop a customized agreement for a million-level ASA chip. In September 2018, the husk bio-lead custom gene chip ASA-CHIA was officially put on the market. Genetic testing is an emerging industry in the 21st century. According to relevant agencies, the number of DTC consumer genetic tests in the United States has reached 12 million in 2017, and the population penetration rate is 3.5%. In the same period in China, the consumption-level genetic test volume is only about 400,000, and the population penetration rate is less than 0.03%. The potential market size in the future is huge and it is a trillion-level industry. For enterprises, solve the pain points of DTC gene sequencing company Husk Bio is a plant-level gene chip testing service provider for DTC consumer genomic testing companies, which addresses the pain points of DTC consumer genomic testing companies. Ma Yukun, the founder of the company, said that the shell organism aims to help potential industry entrants with the ability to interpret the personal genome to enter the industry with a very low threshold, thus fully promoting the development of diversified scenarios of genetic data in the future digital life process. Nutshell Bio Team (Photo courtesy of the company) Based on this original intention, the founding team of the fruit shell biotech breakthrough team, together with many partners at home and abroad, launched the DOUBLE MILLION PLAN and the Chinese population of two million personal genome data plan and 100,000 people open source plan to promote the digital process. Founder Ma Yukun has worked in the genetic testing industry for many years and has a keen insight into the bio-industry. When talking about why he wants to start a business in the middle, he told the Arterial Network that based on the observation of the consumer-grade genetic testing industry, the current DTC companies have some pain points as follows: First, DTC enterprise raw materials (SNP chips) are costly. Second, build a Lab+BT+IT+ report to explain the high cost of the team. Third, the existing products can not meet the DTC needs, especially the ancestral source detection. In response to the above pain points, Ma Yukun thought of several solutions. First, the chip is customized to the upstream, and the ASA-CHIA chip is used to meet the needs of different DTC enterprises, especially the ancestor detection module. The ASA chip has higher test accuracy. At the same time, the B2B gene testing factory provides low-cost, fast and high-quality genetic testing services for DTC companies such as scientific research units and medical companies, including single-site, multi-site and whole-genome detection. The fruit shell creature was officially established in July 2017 with such a mission. Now, Shell Bio can also provide OEM subcontracting services for customized products according to customer needs. Recently, Shell Bio has developed a new project “Gene Story†cloud platform, which is a DNA store, a platform that enables enterprises to provide customized services and user data interaction for their own users. The "Gene Story" cloud platform allows users of B-end enterprises to directly view genetic reports on this platform, and allows B-side enterprises to implement accurate health management of their users' personal and family information, and to achieve between B-side enterprises and users. Interaction to form a new health management model. In cooperation with Illumina, a customized version of the ASA-CHIA gene chip is available ASA (Asian Screening Array) gene chip is the first gene chip for Asian people developed by American chip manufacturer illumina. The chip was officially released to the world in March 2018, providing Asians with more accurate genetic testing services. Compared with the same type of SNP chip, the chip contains 750,000 marker sites, and the number of effective sites accounts for 85%, which means that there are 640,000 effective sites, which is the most effective number of sites on the market. Chip. The more effective sites, the more genetic information that can be detected by genes, and the more valuable the data information obtained by genetic testing. At the same time, the ASA chip is the most widely used chip with low frequency mutation coverage in Asia. The low frequency mutation site refers to a gene locus whose mutation frequency is between 0.01 and 0.05 (MAF is 1-5%), and these low frequency mutation sites are closely related to the onset of many diseases. Based on the standard version of the ASA chip, the shell organism added another 50,000 markers to form a customized version of the ASA-CHIA gene chip. ASA-CHIA has increased the Y-SNPs, MT-SNPs and autosomal-related sites involved in ancestral origin, cardiovascular and cerebrovascular diseases, metabolic diseases, mental diseases, tumors and other complex diseases at the original ASA marker sites. Susceptible sites, genetic disease, hereditary tumors, neonatal birth defects, rare diseases and other disease screening sites, as well as exploratory sites such as personality traits and personal traits. Shell Bio is applying for intellectual property on this custom chip. CTO, the company's CTO, said that the customized version of the ASA-CHIA gene chip was purchased at a low price, which reduced the cost of the entire gene chip by more than double the price of the traditional chip, and solved the problem of high price of the purchased chip for some DTC companies on the market. Consumer-grade genetic testing companies bring more choices. While providing customers with high-efficiency and low-cost gene chips, Shell Bio has its own set of free re-examination guarantee services: When the customer sample detection rate is lower than 97%, the shell bio is free to re-examine the customer; and each A 96-sample test will set up a repeat test for free. If the coincidence rate of the two tests is less than 98%, the shell organism can be re-examined for free again. This kind of protection is rare in the field of genetic testing, so that every customer of the shell organism can get accurate and accurate testing services. In May of this year, the Hull Biological Laboratory was certified by Illumina's global gene chip testing service provider. In June, it obtained the global massarray nucleic acid mass spectrometry service provider certification from Agena, a supplier of nucleic acid mass spectrometry instruments. So far, fruit shell organisms have completed a total of 100,000+ sample size tests. CTO Zhizhihua of the company said that it is expected to complete 200,000 chip inspections this year, and to complete the accumulation of 1 million sample quantities in the next two to three years. It will also cooperate with more manufacturers to introduce more cost-effective omniscience detection technology. Serving DTC companies. At present, the shell organism has completed the tens of millions of angels invested by Beijing Zhengtang Jiaye. It is planned to start the A round of financing in January 2019, mainly for the expansion of production capacity and IVD kit declaration and other projects. Nutshell Bio Mascot: Fruit Shell organisms hope that in the near future, everyone can have their own genomic data as the cornerstone of their own data chain, and then evolve a multi-application scenario. In the future, technology and price will not become the constraints of genomics development as a big health or even precision medicine. At the same time, the security of personal data, including personal genomic data, is solved by the rapid development of blockchain technology. It is time to go. Consider the development of "genomic data +". Bed Sheet,Surgical Bed Sheet,Nonwoven Bed Sheet,Disposable Bed Sheet Xinxiang Huaxi Sanitary Materials Co., Ltd. , https://www.huaximedical.com
