How to effectively eliminate primary tumors, inhibit tumor metastasis and even prevent tumor recurrence? This problem has been receiving much attention in the treatment of cancer. The reporter learned from Suzhou University on the 19th that the research team of the school discovered a new strategy based on biomaterials for radioimmunotherapy, which is expected to become a "breakthrough" to inhibit tumor metastasis and recurrence. The results were recently published in Nature-Biomedical Engineering. In the field of cancer treatment research, it has been the goal pursued to eliminate primary tumors while inhibiting tumor metastasis and even preventing tumor recurrence. Radiation therapy, as a very broad class of tumor treatment technology in clinical application, is usually used to treat local solid tumors, and it is difficult to effectively kill the diffuse tumor lesions after metastasis. "Using natural biomaterials as a link, combined with radioisotope treatment and tumor immunotherapy, may eliminate metastatic tumor lesions and prevent recurrence while destroying visible solid tumors," said Professor Liu Zhuang of Suzhou University. Professor Liu Zhuang teamed up with Associate Professor Yang Kai to mark the radioisotope iodine 131 with therapeutic function on catalase and then mix it with the immunoadjuvant CpG and sodium alginate to obtain a composite injection. Studies have shown that this strategy can completely kill in situ solid tumors in a mouse tumor model, a human xenograft model, and a rabbit tumor model at a lower dose of radioactivity, and further trigger an anti-tumor immune response. By using an immunological checkpoint inhibitor, the body's own immune system can be used to pursue the distantly transferred tumor cells, thereby effectively inhibiting tumor metastasis. In addition, the researchers observed a vaccine-like immune memory effect that protects mice from tumor recurrence. This study mainly relies on enhanced internal radiotherapy to destroy visible solid tumors, further triggering the body's own immune response to eliminate metastatic tumors and prevent recurrence. It is worth mentioning that all the reagents used in this strategy are based on natural biomaterials and have good biocompatibility. This strategy is expected to be applied to the treatment of many types of solid tumors, which may bring new opportunities for advanced patients who have undergone tumor metastasis and cannot be cured by surgery or chemotherapy. (Correspondent Yang Shuting reporter Zhang Wei) Automatic Nucleic Acid Extractor
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