Author: Chen Xi Yuan, Li Xi Sui Release Date: 2018-07-23 The reporter learned from the University of Suzhou on the 22nd that the research team of the school recently proposed a radioimmunotherapy combined treatment based on biological materials, which is expected to inhibit tumor metastasis and recurrence, and bring hope to patients with advanced cancer. Related results were published in the "Nature·Biomedical Engineering". The research was completed in collaboration with Professor Liu Zhuang from the Institute of Functional Nano and Soft Materials of Suzhou University and Associate Professor Yang Kai from the School of Radiation Medicine and Protection. The researchers labeled the therapeutically active radioisotope iodine 131 on catalase, and then uniformly mixed it with the immunoadjuvant cpg and sodium alginate to obtain a composite injection. Among them, catalase as a catalyst can efficiently decompose hydrogen peroxide inside the tumor tissue, generate oxygen, enhance radiotherapy effect; cpg as an immune adjuvant, can trigger anti-tumor immune response; and sodium alginate can interact with tumor cells The ions combine to form a gel, thereby immobilizing the iodine 131-labeled catalase in the tumor, enhancing the catalytic effect, and reducing the radiation side effects of the radioisotope on the normal organs. "Removing the primary tumor while preventing its metastasis and recurrence has always been our goal." Liu Zhuang said that radiotherapy is difficult to effectively kill the diffuse tumor lesions after metastasis, and this study shows that the use of radioimmunotherapy combined therapy The single injection of the program can completely kill the in situ solid tumor in the mouse tumor model, human xenograft model and rabbit tumor model at a lower dose, and stimulate the body's own immune system to pursue the transfer. Tumor cells. In addition, the researchers also observed a vaccine-like immune memory effect that inhibited tumor recurrence in mice. Liu Zhuang said that all the reagents used in this program are based on natural biomaterials and have good biocompatibility. "For mid-late patients who have had tumor metastasis and cannot be cured by surgery or chemotherapy, this may mean new hopes." But Liu Zhuang also said that although this technology has achieved certain results in a large number of animal experiments. However, whether the future can be truly applied to the clinic and achieve the expected results in patients remains to be further studied. (Reporter Chen Xiyuan, Li Wei) Source: Guangzhou Daily
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