Palbociclib is a drug for the treatment of ER-positive and HER2-negative breast cancer developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.
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Palbociclib Intermediates,Cas 571188-59-5,Cas 1013916-37-4,Cas 1016636-76-2 Nanjing Sunshine Biotech Co., Ltd , http://www.sunshine-bio.com
For a long time, it is a kind of artificial plant growth retardant, which promotes the slow growth of stems and leaves, the full maturity of pods, the full fruit rate, and the high rate of rice output. Generally, it increases production by about 10%. The plots with high fertility, high nitrogen fertilizer, and leggy phenomenon were sprayed at a concentration of 1000-150010-6 in the middle of the flowering stage to the middle stage of the crust. Thin ground, poorly developed peanuts should not be sprayed, otherwise it will lead to reduced production.
CCC is generally used in high-fertility, overgrowth, leggy and lodging phenomenon peanut plots, sprayed with 3000 ~ 500010-6 solution at full bloom, can increase production by 5.8% ~ 18.8%.
2,4-D is mainly used for soaking and spraying. The effect of spraying is better during the period of flowering to flowering. The group of trees with a period of 50 ~ 7010-6, can increase production 5% ~ 9.3%; Shenghua period 3010-6, increase production by about 10%.
Trichlorobenzoic acid is a new type of regulator. After the peanuts are sprayed, the plant height increases, the leaves increase and thicken, the chlorophyll content increases, and the photosynthetic efficiency increases. Therefore, the number of single plants, the fruit rate, the single plant weight, the whole fruit weight One hundred and one hundred weight increased, and the rate of double nuts was high. At the beginning of flowering, the spray of 100~30010~6 flower liquid can be increased by about 20%.
It was reviewed and approved under the Food and Drug Administration`s (FDA) accelerated Priority Review and Breakthrough Therapy designation programs on February 3, 2015 as a treatment (in combination with letrozole) for patients with estrogen receptor positive advanced breast cancer.
We produce a series of complete intermediates for Palbociclib, intermediate I (CAS No. 571188-59-5), intermediate II (CAS No. 1013916-37-4) and intermediate III (CAS No. 1016636-76-2) etc.
Increasing production spirit has the function of promoting the operation of nutrients in plants, accelerating cell differentiation, preventing shedding, protecting flowers and protecting fruits, and promoting the role of grain filling and early maturation. During the flowering of peanuts, spraying 10~3010-6 liquids for 1 or 2 times, the rate of follicles is reduced by 10%~20%, and the yield is increased by 10%~15% per 667 square meters, especially when it is used thinly to increase the yield. better.