University of Missouri Research on New Methods of Cancer Targeted Therapy September 27, 2018 Source: Ministry of Science and Technology The University of Missouri research team has recently developed a new method that uses special nucleic acid-based nanostructures to target cancer cells while bypassing normal cells. The research results were recently published in Nature Communications. More than 100 years ago, the German Nobel laureate Paul Ehrlich promoted the concept of "magic bullets" - clinicians will one day be able to attack invading microorganisms without harming other parts of the body. Although chemotherapy is very useful for cancer targeted therapy, its adverse side effects still plague patients. The University of Missouri research team has demonstrated that specialized nucleic acid-based nanostructures can be used to target cancer cells while bypassing normal cells. The research team used a molecular process that mimicked highly accelerated forms to find nucleic acid ligands or aptamers. Due to their three-dimensional structure, aptamers can be trained to bind certain target molecules with high affinity and selectivity. When the target is a cancer-associated receptor, these aptamers can be used as molecular tools for identifying specific diseased cells. The research team "loads" the aptamer with appropriate large fluorescent RNA to produce nucleic acid nanostructures. After incubation with target and non-target cells, only the malignant cells are illuminated by the nanostructures, indicating that the structure has correctly bound to its intended target. The research team will further demonstrate that these aptamers can be loaded with therapeutic molecules that specifically target and treat cancer cells without touching normal tissues. The research highlights the prospect of transforming precision medicine, bringing together industry partners, multiple colleges, and governments at all levels to achieve precision and personalized medicine. The research was funded by the National Institutes of Health. Children Face Mask,Kids Medical Disposable Face Mask,Kids 3 Ply Disposable Face Mask,Kids Nonwoven Disposable Face Mask KUTA TECHNOLOGY INDUSTRY CO.,LIMITED , https://www.kutasureblue.com