Author: Shen Lei Release Date: 2018-07-16 Twenty-three of the 46 people in the family have cancer, including 11 different types of esophageal cancer, breast cancer, stomach cancer, colon cancer, lymphoma, and bone tumor. The age of onset is from 8 to 77 years old, and most patients have died of cancer. Many people are scattered throughout the country and have no regional characteristics. The entire family has been shrouded in deep fear for many years. In March of this year, Li Laobo, 63, from Shuyang County, Jiangsu Province, suffered from an anal tubular adenoma. He was asked for help when he was hospitalized in the Department of Gastroenterology, Huai'an First People's Hospital. He said that after so many years, his family has been leaving, but he has never found a cause. He hopes that the doctor can help him. The Department of Gastroenterology immediately contacted the oncology department, and then the oncology department invited the director of the central laboratory, Wang Qilong. On the second day after Li Laobo was discharged from the hospital, he took his assistant to the old man's house. On the same day, Wang Qilong randomly selected peripheral blood samples from more than 20 people in the elderly, including those who already had cancer and healthy people. Wang Qilong said that cancer is essentially a genetic disease, and almost all cancers are caused by mutations in human genes. There are two types of gene mutations, one is sporadic, that is, the genetic variation that causes cancer occurs in the patient's own body. Such as cervical cancer caused by HPV infection, skin cancer caused by sun exposure. The other is hereditary. From this birth, some or even more genes have been mutated, making them more susceptible to cancer. Subsequently, Wang Qilong team combined with a gene technology company to carry out genome-wide sequencing analysis of the extracted blood samples, through the advanced data mining technology, to obtain the results of the mutation annotation of each sample; and then through the frequency filtering, functional screening, family common mutation site screening Analysis methods such as separation and analysis of small families have finally found that all samples taken have a rare common gene mutation, and there are few reports on this gene in the world. Wang Qilong said that a series of verification work will be carried out according to the research process to determine the correlation between the gene and the tumor. However, since this consensus mutation has been found on all samples, it is empirically confirmed that this family of cancers is associated with this. Source: Health News Network
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