Assistive effects of statins on the immune system September 26, 2016 Source: Noble Statins prevent cardiovascular disease more than previously thought. In one study, researchers from the Karolinska Institute showed the immunological effects of statins and presented a new hypothesis about why statins are effective in preventing heart attacks. The study was published in the Journal of the American Heart Association. Atherosclerosis can lead to a range of serious medical conditions such as heart attack, stroke and intermittent claudication. These cardiovascular diseases and other cardiovascular diseases are increasing all over the world. In the West, they are the main cause of death. Johan Frostegrd, professor of environmental medicine at the KI Institute, has been interested in the underlying causes of atherosclerosis and chronic inflammation. Atherosclerosis is a visible plaque on the walls of blood vessels, consisting of dead cells and oxidative LDL cholesterol (so-called "bad" cholesterol) and two types of immune cells - T cells and dendritic cells. T cells and dendritic cells are major players in chronic inflammation. Statins are a common class of drugs commonly used to prevent cardiac arrest. Although statins have long been known to have anti-inflammatory effects, it is not yet clear whether the immune system is affected. The reason why statins are effective is because they lower the level of cholesterol in the blood. "We can demonstrate how statins prevent cardiovascular disease through a new specific immune mechanism and believe this can explain their beneficial effects," said John Frosttegrd, professor of environmental medicine at the Karolinska Institute. "This is For the first time, we demonstrate the feasibility of immunotherapy for atherosclerosis." When discussing the side effects of statins, whether or not they may have carcinogenic properties needs to be addressed. Although large meta-analyses have shown a reduction in most tumors, in this study, statins have been found to inhibit gene activators (microRNAs), including a gene activator called let7c, which usually has Helps inhibit tumor growth. In this study, let7c is involved in oxidative low-density lipoprotein-induced T cell activation. "Statins can strongly suppress let7c," Professor Frosttegrd said. "If let7c plays an important role in tumors in cancer patients, the effects of statins may be unfavorable. At the same time, statins can reduce inflammation and can reduce Risk of cancer, large meta-analysis shows no general increase in cancer risk Smart Fire Protection System,Fire Alarm System Transmission Device,Fire System Protocol Converter,Protocol Converter Fire Device LIAONING YINGKOU TIANCHENG FIRE PROTECTION EQUIPMENT CO.,LTD , https://www.tcfiretech.com