Release date: 2014-06-16 Two separate silver nanoparticles (red and green) target prostate cancer cells Beijing time on June 10th news, Science Daily reported that scientists at the University of California, Santa Barbara recently designed a pair of unique and important features of nanoparticles. The composition of this spherical particle is silver, which is encapsulated inside a peptide-coated shell that allows it to attack tumor cells. In addition, the shell is etched, so those nanoparticles that do not attack the target decompose and eliminate themselves. The study was published in the journal Nature Materials. The core of nanoparticles utilizes a phenomenon called plasmonics. In plasmonic optics, nanostructured metals, such as gold and silver, resonate when illuminated by light and concentrate on the geomagnetic field near the surface. In this way, the fluorescent dye is enhanced to appear to be 10 times brighter than the natural state—that is, when no metal is present. But when the core is etched, this enhancement disappears and the particles become dim. The Russell Research Laboratory at the University of California, Santa Barbara, invented a simple etching technique that uses biocompatible chemicals to rapidly decompose and remove silver nanoparticles from outside the living cells. This approach leaves only intact nanoparticles for imaging or quantification, revealing which cells are targeted to attack and how much each cell is internalized. “This breakdown is an interesting concept for creating drugs that respond to specific stimuli.†Postdoctoral Fellow at the Lus Ossati Laboratory of the School of Molecular, Cellular and Developmental Biology (MCDB), Stanford-Sanford Bernard Gary Braun of the Institute of Medical Research said. “By decomposing excess nanoparticles and cleaning them through the kidneys, it minimizes toxicity from the target.†This method of removing nanoparticles that are incapable of penetrating the target cells is unique. "By focusing on the nanoparticles that actually enter the cell, we can understand which cells are the target and study the tissue transport channels from a more detailed perspective," Braun said. Some drugs can penetrate the cell membrane by themselves, but many drugs, especially RNA and DNA gene drugs, are charged molecules that are blocked by cell membranes. These drugs must enter the cell by endocytosis, during which the cells engulf and absorb the molecules. “Using nanoparticles as a carrier is generally needed to protect the drug and escort it into the cell,†Braun said. “And that's exactly what we want to measure: the internalization of the carrier by endocytosis.†Because nanoparticles have a core shell structure, researchers can achieve different surface coatings and compare the efficiency of individual tumor selection and internalization. The target selection of different diseases - or the target organism of the bacterium - is achieved by switching surface agents using different target receptors. According to Braun, this approach should be able to develop a method of maximizing drug delivery. "These new nanoparticles have some great properties that have proven to be a very useful tool in research related to the delivery of targeted drugs to tumors." University of California, Santa Barbara, Nanomedical Center and MCDB Academy Professor Erkki Ruoslahti said this. “They also have potential applications in the treatment of infections. Hazardous infections caused by bacteria that are resistant to all antibiotics are becoming more common, and there is an urgent need for new ways to solve such problems. Silver is often used as an antibacterial agent, and our goal Technology may or may use silver nanoparticles to treat infections anywhere in the body into reality." Source: Phoenix Technology Wiggle wire lock is designed to be used with poly lock base cap- sold separately. Greenhouse wiggle wire and base care are an effective method of attaching your poly film roof and or shade cloth. The greenhouse wiggle wire lock will hold form 4 mil to 20 mil thickness of material. Use one wire to hold the roof in place and then add a second wire to hold your shade cloth. When it is time to remove the shade cloth, you will not disturb the roof plastic. Greenhouse Wiggle Wire,Greenhouse Steel Wire,Greenhouse Spring Wire JIANGSU SKYPLAN GREENHOUSE TECHNOLOGY CO.,LTD , https://www.thgreenhouse.com
Universal Base (WIG2000)- used on the curved surface, i.e. the arch for attaching the end wall covering.
Standard Base (WIG1000) - used along the straight lengths of your greenhouse.