Medicine Peptides and protein drugs are emerging. There are now 35 important therapeutics on the market, and the development of biotechnology and biopharmaceutical companies is becoming increasingly global. Biotechnology drug research focuses on the application of DNA recombinant technology to develop peptides, proteins, enzymes, hormones, vaccines, cell growth factors and monoclonal antibodies that can be used in clinical applications. According to Parexl's Pharmaceutical R&D Statistical Source Book, there are currently 723 biotech drugs under FDA review (including phase â…° to iii clinical and FDA evaluation), 700 drugs are in early stage (research and preclinical). More than 200 additional drugs are in the final stage of approval (Phase iii clinical and FDA evaluation). The basic dosage form of biotech drugs is lyophilized. Although the efficacy of conventional preparations has long been clinically proven, they need to be injected frequently for a long time due to their short half-life, which is difficult to accept from the perspective of psychological and economic burden on patients. To this end, scholars around the world mainly from two aspects to study and develop convenient and reasonable drug delivery approaches and new preparations: (1) embedment agent and sustained-release injection. â‘¡ Non-injectable dosage forms, such as respiratory inhalation, rectal administration, nasal administration, oral administration and transdermal administration, etc. Injectable preparations of sustained-release biotechnological drugs are new dosage forms with promising applications. Some of them, such as microsphere injections of luteinizing hormone releasing hormone (LHRH) analogues which can be sustained-release for 1 to 3 months, have been on the market. This paper focuses on this kind of preparations.Main types of peptides and protein drug sustained-release preparations The research and development of peptides and protein drug sustained-release preparations can be divided into two types, namely, embedment agent and microsphere injection, from the perspective of development process and dosage form. The shape of the implant is a hollow micro-fine rod, one end is closed, the other end is open, and the rod material is non-biodegradable polymer such as ptfe. The lumen was filled with a mixture of drugs and silica gel (silastic, polydimethylsiloxane). The implant is embedded under the skin, and the drug is released slowly through the opening of silica gel matrix. The American Physicians' Handbook (PDR) contains a product called Norplant? Levo-18 ethyl norethinnes, used in family planning. The preparation, each with a diameter of 2.4 mm and a length of 34 mm, is surgically implanted in the inner side of the patient's upper arm with 6 thin rods. The drug can be released in the body in zero-grade mode for up to 5 years, and then removed by surgery after release,1.1.2 Micro-osmotic pump embedding agent The United States Alza company in the 1970s developed an embedding agent shaped like a capsule, which is embedded in the skin or other parts. The body fluid can penetrate through the shell, dissolve the interlayer electrolytic layer, make the volume expansion of the interlayer pressure to the plastic inner cavity, and promote the drug solution from the opening of the fixed speed release. Many biomolecular drugs, such as insulin, heparin and nerve growth factor, have been reported as model drugs in vivo and in vitro. Implants have positive significance for the treatment of chronic patients who need long-term medication, but it has the following defects: â‘ must be surgically implanted. â‘¡ The skeleton material of the preparation is non-biodegradable polymer, which needs to be removed by surgery after release. â‘¢ The preparation has irritation and discomfort in local tissues. Evaluation methods for polypeptide protein drugs: 1. Liquid chromatography 2. Spectroscopic 3. Solvent-based versions are easy to use, but need to be kept at low temperatures (2-8 degrees Celsius). medicine peptides high,Peptide injections,buy medicine peptides high,medicine peptides for bodybuilding,medicine peptides for hgh Shaanxi YXchuang Biotechnology Co., Ltd , https://www.peptide-nootropics.com
In the spring: The breeding and management of the bees colony on the ground and in small turns are followed by double nests, disease prevention and control, organization of production groups, replacement of old queen bees, and prevention of theft of bees. For the swarms of bees that have been transferred to other provinces, their rearing and management are in batches followed by boxes, to prevent the powder from pressing on the ovum, to separate the bees from the king, to prevent natural bees, to transfer to the ground, to pay attention to the safety of bee colonies, and to prevent worker bees. Partial set, adjust the group potential, take the honey to collect pulp, chase flowers and win the honey, and prepare again for transshipment. In the summer, the rearing and management of the bees colony on the ground and in small areas is followed by leaving enough feed to prevent the theft of bees, selecting a good melon flower field, producing royal jelly, controlling bee stings, grasping breeding well, preventing heatstroke, and preventing predators. Transferred to other provinces to transfer to the bee colony, their feeding and management followed in order to chase flowers and honey, according to different sources of honey do a good job in management, to prevent the poisonous plant honey (powder) source poisoning, collecting honey slurry, cultivate new king, store honey Powder spleen. In the fall season, the rearing and management of the bee colony on the ground and in small areas is followed by the cultivation of overwintering bees, the prevention of the theft of bees, the storage of pollen, the fumigation of the nest spleen, the claustrophobic queen bee, the feeding of bees, the control of flight, and the inspection of queen bees. Transferred to other provinces to the large bee colony, their feeding and management in order to prevent the theft of the bee, the queen of claustrophobic, merger weak group, feed enough feed, first in the field or in the local more early winter, make plans and carry out honey source survey. In the winter season, the feeding and management of the ground bees and small bee colonies are followed by inspection and evaluation of bee colonies, feeding of feedstuffs, observation outside the box, proper insulation, keeping the bees quiet, avoiding sunlight stimulation, tidying the spleen, and swiftly breeding. Transferred to other provinces to the large swarm of bees, their feeding and management in order to enter the market in a timely manner, timely packaging, adjust the group potential, cure the spleen, strengthen insulation, foster drones. China Agricultural Network Editor