Studying DNA from more than 1.5 million people, an international research team led by the University of Washington's St. Louis Medical School and the University of California, San Francisco, has identified DNA sites that increase cardiovascular risk, and this DNA site has also increased Alzheimer's. The risk of illness. Scientists have long recognized that there is a link between the mutation of the APOE gene and Alzheimer's disease, which involves cholesterol and lipid metabolism. It is well known that this gene doubles the risk of Alzheimer's disease in some patients and 12 times in other patients. But in this new study, the researchers found that other DNA spots also appear to be associated with cardiovascular disease risk and Alzheimer's risk. The findings were published in the journal Acta Neuropathologica on November 12. Dr. Celeste M. Karch, assistant professor of psychiatry at the University of Washington School of Medicine, said: "These findings represent an opportunity to consider reusing drugs for lipid metabolism pathways." "With these findings, we can begin to consider these drugs. Whether some of them may help prevent or delay Alzheimer's disease, our study emphasizes that understanding how genes drive Alzheimer's disease also increases the risk of other health problems, especially cardiovascular disease, and vice versa. Also. So we really need to consider these risks more comprehensively. " This study is the largest genetic study of Alzheimer's disease. Karch is one of his co-authors and is also Dr. Rahul S. Desikan, Assistant Professor of Neuroradiology at the University of California, San Francisco. The first author of the study was Dr. Iris Broce-Diaz, a postdoctoral researcher at the Desris Medical Laboratory. They studied DNA differences in factors that lead to heart disease or Alzheimer's disease and identified 90 points in the genome that are associated with the risk of both diseases. Their analysis confirmed that six of the 90 points had a strong effect on Alzheimer's disease and elevated blood lipid levels, including several of the genes previously not associated with the risk of dementia. These include several points in the CELF1 / MTCH2 / SPI1 region on chromosome 11, which were previously associated with the immune system. The researchers confirmed that these same risk factors are more common in people with a family history of Alzheimer's disease, even if they do not suffer from dementia or other symptoms such as memory loss, their large genetics in healthy adults. The study confirmed their most promising findings. They focus on specific risk factors for heart disease - such as high body mass index, type 2 diabetes and elevated levels of triglycerides and cholesterol (HDL, LDL and total cholesterol) - to see if any of these recognized risk factors are also associated with heart disease The risk of Alzheimer's disease is genetic. "Genes that affect lipid metabolism are genes associated with the risk of Alzheimer's disease," Karch said. "Genes that cause other cardiovascular risk factors, such as body mass index and type 2 diabetes, do not appear to have a genetic risk of Alzheimer's disease." Desikan said that although more research is needed, new research suggests that by targeting the right genes and proteins, it is possible to reduce the risk of Alzheimer's disease in some people by controlling cholesterol and triglycerides. . "These results mean that no matter what causes it, the pathology of cardiovascular and Alzheimer's disease coexist because they are genetically related. That is, if you carry this small part of the genetic variation, you may not only face Heart disease, but also the risk of Alzheimer's disease," he said. Sinoscope Electric Drill,Nose Ent Instrument,Ent Sinus Electric Drill,Ear Electric Drill ZHEJIANG SHENDASIAO MEDICAL INSTRUMENT CO.,LTD. , https://www.sdsmedtools.com