The mechanism of death of the new Bunia virus is revealed September 4, 2018 Source: Health News Recently, Dr. Song Peixin, from the Department of Infectious Diseases of the Affiliated Drum Tower Hospital of Nanjing University School of Medicine, conducted research on the fatal new type of Bunia virus infection, which was published online in the international academic journal Nature-Communication. The study revealed for the first time that a severe virus-specific humoral immune deficiency has played a key role in the death of patients with severe fever with thrombocytopenia syndrome. This study provides insight into the pathogenesis of the disease and the development of effective prevention in the future. And treatment has important guiding significance. According to reports, severe fever with thrombocytopenia syndrome is a new infectious disease, mainly in China, Japan and South Korea. The pathogen of the disease "New Bunia Virus (SFTSV)" was first discovered by Chinese scholars in 2010. It has been confirmed that the disease is mainly transmitted by mites and bites, and in addition, direct contact with blood of acute phase patients can also infect the virus. Because of its high mortality rate, it poses a serious threat to public health security in East Asia, but there is still a lack of in-depth understanding of the pathogenesis of the disease. The results showed that the extracellular segment of the viral envelope protein successfully synthesized by the research team had good water solubility and immunogenicity. Animal experiments confirmed that the polyclonal serum against the synthetic protein has good virus neutralization activity. The development of preventive vaccines and therapeutic neutralizing antibodies has laid a solid foundation in the future. The researchers found that the antibody response to the envelope protein and nucleocapsid protein was severely deficient in the patient's serum antibody response, and even the immunoglobulin antibody response to the nucleocapsid protein was in a missing state. In addition to revealing the key role of virus-specific humoral immune response in pathological mechanisms, this important phenomenon also suggests that routine serological diagnosis methods can easily lead to missed diagnosis of critically ill patients, making them lose important treatment opportunities. Through research on the mechanism of in vivo and in vitro models, the research team found that the virus has direct and significant cytotoxicity to antigen-presenting cells such as dendritic cells, which interferes with the main link of B cell immunity, leading to specific humoral immune responses. failure. The study was completed by a team of researchers from the Infectious Diseases Department of the Affiliated Drum Tower Hospital of Nanjing University School of Medicine and a team of public health research centers of the Nanjing University School of Medicine. (Special correspondent Liu Huiyan reporter Cheng Shouqin)
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