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Recently, a research report published in the international journal Cancer Letters, scientists from Weill Cornell Medical School found that if used together, an existing malaria drug or It can improve the effect of anti-cancer therapy of glutaminase inhibitors.
In this study, the researchers conducted an in-depth analysis of the metabolic processes of cancer cells and found that an FDA-approved antimalarial drug called chloroquine or a treatment that enhances novel glutaminase inhibitors. Effect, current
Global pharmaceutical companies are able to develop glutaminase inhibitors, and related research findings may provide clinicians and researchers with a relatively simple way to improve the treatment outcomes of cancer patients treated with glutaminase inhibitors.
Glutamine enzyme inhibitors can target the process of glutamine decomposition (the process by which glutamine is broken down), which releases energy to help cancer cells grow, while glutaminase inhibitors can destroy the process and deprive The source of energy for cancer cells slows or blocks the growth of cancer cells; however, specific cancer cells can activate another pathway to generate energy and evade the targeted killing of drugs, which is what researchers are currently using. A new research method called "rational metabolic engineering".
Researcher Dr. Anna Halama said that when we exposed the cancer cells grown in the laboratory to different doses of anticancer drugs, we then used metabolomics to determine the changes in almost all small molecules present in the cells, in complex computer models. With help, we can identify which molecules the cancer cells use to evade the drug, and we can also find ways to stop the cancer cells from escaping/escape. After the first application of glutaminase inhibitors, the researchers focused on two specific energy pathways used by cancer cells, one of which is the lipid catabolic pathway, the process of fat breakdown, and the other is cells. The autophagy process, in which cells acquire energy by decomposing their own structures, is accelerated when the drug is used to inhibit the decomposition of glutamine, thereby promoting the survival of cancer cells.
Because chloroquine can interfere with some of the energy production mechanisms, the researchers believe that combining quinquinine with a glutaminase inhibitor can improve tumor cell suppression, and the experimental results show that this is indeed the case. The researchers say that the beauty of metabolomics analysis is that it allows us to see the metabolic behavior of cells at different conditions/levels. Using relevant research techniques, we can clarify the effects of specific drugs on the metabolic mechanisms of cancer cells. This helps us understand the mechanisms underlying different diseases and identify targets for developing new potential therapies.
Next, the researchers plan to test the effects of the antimalarial drug chloroquinein combined with glutaminase inhibitors in clinical trials. Finally, the researcher Khaled Machaca said that in the later stage, we need to conduct more in-depth studies to elucidate chloroquinine. The molecular mechanism of combination therapy with glutaminase inhibitors in inhibiting the progression of cancer cell proliferation provides a basis and idea for developing new strategies for treating cancer or improving the efficiency of cancer therapy.