Release date: 2017-07-14 Osteosarcoma is one of the most common forms of bone cancer, and the development of osteosarcoma is often challenging. Recently, a study published in the international journal PNAS, from the University of Texas MD Anderson Cancer Center Researchers have discovered that a drug called the bone metastasis mimic peptide (BMTP-11) may be effective in the treatment of osteosarcoma. In preclinical studies, the investigators observed the efficacy of BMTP-11 alone and gemcitabine in the treatment of osteosarcoma; although osteosarcoma is a relatively rare cancer, it also causes death in children and adolescents aged 10-20. One of the main reasons is that the 5-year survival rate of patients has not improved in the past 25 years, and the choice of treatment for osteosarcoma patients is very small; in addition, currently available therapies tend to produce some obvious in the treatment of osteosarcoma patients. Some side effects can cause other serious health problems and cause damage to the main organs of the patient. Researcher Dr. Valerae O. Lewis said that the novelty of this treatment is that BMTP-11 can target tumors without affecting other organs; I think this study laid the foundation for a new clinical trial of osteosarcoma. Good foundation. In the article, the researchers found that IL-11Rα is a receptor on the surface of osteosarcoma cells, which is directly related to tumor progression and prognosis in patients with osteosarcoma, and IL-11Rα and IL-11 are in human metastatic osteosarcoma cell lines. It is also in an up-regulated state, which is also associated with the occurrence of lung metastasis in a mouse model. The targeting of IL-11Rα may be able to modulate the metastatic potential of osteosarcoma cell lines, and death from respiratory failure induced by lung metastasis remains an important health problem for patients with osteosarcoma. Researcher Pasqualini pointed out that in this article we have clarified how to effectively treat osteosarcoma, considering the first use of BMTP-11 for human trials, which of course may provide a basis for our early clinical trials of early transformation in osteosarcoma patients. This study lays a foundation for the development of new potential therapies for the treatment of osteosarcoma and the development of a second-line combination therapy system with conventional chemotherapy plus the candidate drug BMTP-11. Of course, this requires the unremitting efforts of the researchers. achieve. Source: Bio Valley One Button Flash Test Splicing Instrument Introduction
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