The article "Restoring visual function to the blind retina with a potent, safe and long-lasting photoswitch" published in the April 13 issue of Science Report proposes a new compound that can help the retina of blind mice to temporarily restore visual response.

Nature:最新化合物可帮助失明老鼠恢复视觉响应

As an optical switch, BENAQ is able to restore vision more effectively and permanently. Tochitsky et al.

Macular degeneration caused by retinitis pigmentosa and aging is the two major degenerative diseases of the eye. The affected person will have decreased visual cells and cones, leading to visual loss or even complete blindness. Optical switches are one of a series of technologies that are being developed to help restore vision.

Nature:最新化合物可帮助失明老鼠恢复视觉响应

BENAQ selectively produces photosensitivity of diseased retinal ganglion cells. Tochitsky et al.

An optical switch is a molecule that produces light sensitivity to the ion channels of the eye, allowing neuronal activity to be controlled by light. A previous optical switch called DENAQ helped restore the photoreactivity and visual behavior of the retinal pigmented rodent's retina, but the dose required was large and the effect disappeared within a few days after treatment.

Nature:最新化合物可帮助失明老鼠恢复视觉响应

BENAQ did not show significant toxicity. Tochitsky et al.

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