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NO.1 GemCode Platform (GemCode sequencing platform)
Company: 10X Genomics (founded in 2012, headquartered in Pleasanton, California, USA)
Time to market/launch: February 2015 Product introduction: The GemCode platform is equipped with a set of molecular barcodes and analysis systems consisting of chips, gel beads, library reaction kits and informatics software, similar in appearance to benchtop PCR machines.
The workflow of the system: first add DNA samples to the GemCode chip, and add gel beads and liquid separation oil. In the instrument's microfluidic system, the split oil dispenses the sample to a size of 100 bp and is incorporated into a gel bead with a specific primer label (compatible with Illumina sequencing). Subsequently, these gel beads dissolve the release primers and initiate library construction. Then, GemCode informatics software can connect separate short reads to produce new data types: linked reads.
In this way, researchers can use the GemCode platform and the original Illumina sequencer to get long pieces of information. Moreover, the connection read data can detect haplotype and structural variation (missing, duplication, etc.), and achieve genome-wide sequencing with 25-fold coverage, thereby obtaining genomic information more accurately.
Technology breakthrough: The GemCode platform has the advantage of accurately reading structural variations, haplotypes and long fragment genes for targeting, exome and whole genome sequencing. By combining with a short-reading sequencer, the current sequencing requirements are met. It is currently compatible with Illumina's sequencers.
Price: $7,500. Consumables cost about $500/sample.
Company: Illumina
Time to market/launch: January 2015 Product introduction: The MiSeq FGx Forensic Genomics System is the first fully validated sequencing system for forensic genomics applications. The system is based on the second-generation sequencing technology, which has traditionally used low-resolution capillary electrophoresis sequencing to bring high-resolution genetic sequencing innovation to forensic laboratories.
MiSeq FGx is matched to a specific equipment system, including custom control software and analysis software, and a dedicated forensic library construction kit. The system's DNA primer design can exceed 200 sites, including multiple short tandem repeat (STR) markers (usually used for forensic analysis), as well as some SNPs (covering performance traits and genetic traits). Highly accurate base-by-base sequencing by SBS technology.
Technical advantages: The MiSeq FGx instrument can perform complex phylogenetic identification and can process highly degraded DNA samples or mixed samples. The instrument offers an unprecedented opportunity to mine evidence that is difficult to find using traditional methods.
Company: Thermo Fisher Scientific
Time to market/launch: September 2015 Product introduction: Ion S5, Ion S5 XL two sequencing systems based on Ion Torrent technology (founded by Rothberg in 2007), complete DNA-to-data complete targeted sequencing in 24 hours Process.
The Ion S5 and Ion S5 XL systems will be able to combine multiple gene panels with small genomes to customize different test samples on a single platform. The design concept of the platform is “plug and playâ€. For example, the cartridge type loading simplifies the setup process before sequencing. The manual time of loading, building, and template preparation takes only 45 minutes. Technical advantage: IonS5&S5XL has simple and flexible It has five characteristics: speed, low sample input, and simple data analysis and storage. It can be used in research fields such as cancer, genetic diseases, aneuploidy screening, and infectious diseases. The system uses IonAmpliSeq technology to process small or low-quality samples with only 10 ng of DNA or RNA for sequencing.
Price: IonS5 is priced at $65,000. The S5XL is equipped with internal hardware and an external server, allowing for faster processing and continuous operation, so it costs $150,000.
Company: Horizon Discovery
Time to market/launch: May 2015 Product introduction: On Demand Deletions Human Hap1 cell beads are based on CRISPR technology for the deletion of specific genomes. Hap1 is an immortalized cell line similar to fibroblasts, which is close to haploid, and most of the chromosomes are made up of one copy.
Last year, Haplogen (now part of Horizon) was able to insert or knock out the coding region of the human genome by virtue of the Human Gene Knockout Cell Pearl. Cell beads introduced in May this year can knock out genes with larger lengths.
Technical advantage: With the "Magic Scissor" technology, the genome can be specifically modified and the edited cells can be obtained within 12 weeks.
Price: $3,400 per cell line.
Company: Promega
Time to market / launch time: February 2015 Product introduction: Protein interaction is the most important step in understanding cell physiology, especially how to study how drugs respond in cells. The NanoBiT Dual Luciferase Assay Kit contains two luciferases (18 kDa and 1 kDa peptide) for quantitative analysis of protein interactions with enhanced sensitivity.
Technical advantages: Compared to similar kits, NanoBiT can detect and analyze protein interactions with low expression levels and can be applied to cell types that are difficult to transfect. This technology no longer requires high peaks in protein, and is an innovation in prior art, so it has a broad application prospect.
Price: about $1,000.
Company: Sigma Aldrich
Time to market/launch: September 2015 Product introduction: The research team led by Sigma Aldrich's chief scientist, Qingzhou Ji, has expanded the use of CRISPR technology from editing genes to editing epigenetic levels.
The CRISPR epigenetic catalyst modulates the genome by acetylating specific histones, activating the target gene, and modifying the genome without changing the DNA sequence. Ji likes epigenetic catalysts as the key to entering the room: we want to know what's going on inside the room, but we don't want to disturb the layout of the room. We just want to open the door and walk in.
Price: $995
Company: Perkin Elmer
Product introduction: The Phenoptics system was developed by the University of California Paul Tumeh research team and Perkin Elmer scientists for three years. As a new system, Phenoptics can quantitatively analyze in situ immune cells of formaldehyde-fixed tissues, and connect to a computer to visualize time-space images, thereby obtaining immune cell density and location in patients before and during treatment of melanoma with anti-PD-1 antibody. , related cell types and other related data. The research team's relevant results were published in the November 2014 edition of Nature.
The Phenoptics system includes staining kits, imaging systems, and analysis software. Combined with advanced staining methods, multi-spectral imaging systems, and image analysis software, the Phenopsis system is in its infancy, but will be widely used in clinical applications of immuno-oncology.
Technical advantages: The Phenoptics system provides researchers with a visual analysis of immune cell and tumor cell interactions, which can solve multiple biomarkers in a single tissue section, allowing clinicians and researchers to obtain more information about cancer mechanisms and immunotherapy.
Price: Estimated $140,000 to $350,000.
Company: Seahorse Bioscience
Time to market/launch: November 2015 Product introduction: The XFp Cell Energy Metabolism Test Kit is capable of simultaneously measuring the metabolism of two major energy transduction pathways (glycolytic and mitochondrial respiration) in living cells.
The kit comprises: 12XFp reagent, a secret fluorescent agent assembled to the transient microspheres, and a drug injection port into which various compounds can be introduced for culturing the detection cells. This reagent system responds to metabolic differences by measuring mitochondrial respiration and glycolysis in real time.
Technical advantage: XFp is the only kit that can be used to measure the metabolic potential of cells. And the reaction time is about 1 hour, and the sensitivity is high.
Price: USD 299
Company: Celsee Diagnostics
Time to market/launch: Product introduction in early 2015: Liquid biopsy is gaining attention as a minimally invasive technique in the field of cancer detection. Analysis of circulating tumor cells (CTC) in the blood allows for clinical assessment of early tumor prediction, drug efficacy, and recurrence monitoring.
As a sample preparation system, Celsee PREP400 utilizes microfluidic dynamics to achieve multi-channel, fully automated processing of blood samples and enrichment of CTC cells. The system is capable of handling large numbers of blood samples without the need for pre-treatment. Celsee Diagnostics has begun applying to the FDA for clinical approval of the Celsee PREP400.
As an image analyzer, Celsee ANALYZER captures images of CTC cells and performs highly automated, high-throughput analysis of numbers and cell types.
Price: about $150,000, and the company said it would offer a discount to research institutions.
Time to market / launch time: June 2015 Product introduction: Nanolive's 3D cell microscope uses the principle of multi-angle light refraction, and the laser can be used for internal observation of living cells at 360 degrees, and the detection distance can reach 200 nm. The microscope can be connected to a computer to obtain grayscale images. With the software of the holographic algorithm, the user can digitally stain the cells to obtain a high resolution 3D image.
Technical advantage: The three-dimensional structure of the cell is obtained by rotating, scanning the sample, combining the internal components of the cell and the optical density to calculate the refractive index of each part of the cell. At the same time, special physiological and biochemical processes such as cell fertilization and division can be observed in real time.
Price: 22,000 US dollars
[China Pharmaceutical Network Technology News] The year is approaching, all major portals have opened up the trend of inventory. And 2015 is undoubtedly a fruitful year for innovation breakthroughs. Just a few days ago, The scientist launched the 2015 Top Ten Bio-Innovative Product Rankings. Let's take a look at what products are on the list.
NO.2 MiSeq FGx Forensic Genomics System (the first NGS system for forensic genomes)
NO.3 Ion S5 & Ion S5 XL (two NGS sequencers)
NO.4 On Demand Deletions in Human Hap1 Cells (CRISPR Gene Editing Cell Line)
NO.5 NanoLuc Binary Interaction Technology (Dual Luciferase Assay Kit for Validation of Protein Interactions)
NO.6 CRISPR Epigenetic Activator (CRISPR Epigenetic Catalyst)
NO.7Phenoptics (Quantitative Pathology Imaging System for Immunotherapy)
NO.8 XFp Cell Energy Phenotype Test Kit (XFp Cell Energy Metabolism Test Kit)
NO.9 Celsee PREP400 and Celsee ANALYZER (Circulating Tumor Cell Enrichment and Imaging Detection Platform)
NO.10 3D Cell Explorer
Company: Nanolive SA