The human body has highly precise and complex biological signals. Each kind of signal transmits the working state of the body, whether the organ function is normal, whether the breathing and circulatory system are sound, whether the human body is in a healthy state... With the development of information technology In the field of medical research, doctors have produced "high-end" who receive human body signals to detect human body information and realize disease diagnosis and prevention.

Biomedical sensors are like the facial features of human beings. People perceive and accept external information through facial features, namely, eye (visual), ear (auditory), nasal (smell), tongue (taste) and limbs (tactile), and then transmit it to the brain through the nervous system. Processing. The sensor is a "electricity five senses" of the measurement control system. He senses the external information and sends it to the system's processor for processing. If a system does not have a sensor, it is equivalent to a person without five facial features.

Biomedical signal processing is an important research field in biomedical engineering. It is also an important application aspect of the rapid development of digital signal processing technology in recent years. It is precisely because of the close combination of digital signal processing technology and biomedical engineering that we have made us New means have been used in the detection, extraction and clinical application of biomedical signal features, which has also helped us to deepen our understanding of the human body.

Analysis of biomedical signals and sensors

Biomedical sensor awareness

A sensor is a device or device that can sense (or respond to) a specified measured and converted to a usable signal output according to certain rules. The sensor typically consists of a transducer element that directly responds to the measured sensitive component and produces a usable signal output, as well as corresponding electronics. The sensor can also be narrowly defined as a device or device that can convert an external non-electrical signal into an electrical signal output.

Biomedical sensors are a special kind of electronic device that can convert non-electricity in various biomedical observations into observable electric quantity and expand human sensory functions. It is a kind of medical analysis and diagnostic instruments and equipment. The key components. We divide the sensors commonly used in biomedical sensing technology into the following three categories according to the amount of observation:

(1) Physical sensor: It is used to measure and monitor the physical quantity of blood pressure, respiration, pulse, body temperature, heart sound, electrocardiogram, blood viscosity, flow rate and flow rate of the living body.

(2) Chemical sensor: used for odor molecules in organisms, pH in body fluids (blood, sweat, urine, etc.), oxygen and carbon dioxide content (pO2, pCO2), Na+, K+, Ca2+, Cl-, and heavy metal ions The detection of chemical quantities.

(3) Biosensor: It is used for the detection of biomass, such as tissues, cells, enzymes, antigens, antibodies, receptors, hormones, cholic acid, acetylcholine, serotonin, DNA, RNA and protein. ? Sensors are sized by conventional sensors (millimeters for tissue testing), microsensors (micron for cell detection) and nanosensors (nanoscale for intracellular detection).

Performance requirements for sensors

(1) has higher sensitivity and signal to noise ratio. When the sensitivity is high, a smaller signal can be input to generate a larger output signal. The ratio of the sensor output signal voltage to the noise voltage is called the signal to noise ratio. The higher the signal-to-noise ratio, the larger the useful output signal obtained. The smaller the signal-to-noise ratio is, the harder it is to distinguish the signal and the noise. In severe cases, the signal will be overwhelmed by noise, and the useful signal cannot be obtained. The measurement is invalid.

(2) Have good linearity and high response speed?

Good linearity means that the output signal of the sensor is proportional to the output signal within a specified operating range without generating signal nonlinear distortion. The fast response time indicates that the output and input delay time is short and the real-time performance is good.

(3) Is repeatability, consistency and selectivity good?

Good repeatability means that the sensor is used repeatedly and its performance is unchanged. Good consistency means that the sensor is highly interchangeable and is especially important in production and repair. Good selectivity means that the sensor responds only to variables that determine the target and is not affected by other variables.

(4) Good chemical and physical properties?

The sensor must be compatible with the body's chemical composition and will not corrode or cause toxicity to the human body. The shape, size and structure of the sensor should be adapted to the anatomical structure of the part to be tested, and the impact on the object to be measured should be small, and the tissue should not be damaged during use.

(5) Electrical safety is good. The sensor should be electrically insulated from the human body. Even in the case of sensor damage, the shock received by the human body should be safe.

(6) Good operability. The sensor should be easy to operate, easy to maintain, and easy to disinfect.

The significance of biomedical sensors

With the continuous development of biosensing technology, biosensors will surely set off a boom in the medical field.

(1) Biosensors use immobilized bioactive materials as catalysts, and expensive reagents can be used repeatedly, which overcomes the shortcomings of high cost of chemical reagents and complicated and complicated chemical analysis. Therefore, the cost of this technique is low, and in the case of continuous use, only a few cents of RMB is required for each measurement, and the burden on the medical expenses of the patient is largely reduced.

(2) The biosensor has strong specificity and only reacts to specific substrates, and is not affected by color and turbidity. The accuracy is high, and the relative error can reach 1%. The analysis speed is fast and can be obtained in one minute. result. Therefore, the application of this technology to medical not only improves the accuracy of the test results, but also shortens the time required for the entire process, and further provides an opportunity to treat patients.

(3) The operating system is relatively simple and easy to implement automatic analysis. In the clinic, many operations are painful for patients. If you can make good use of this feature of biosensors, I believe it will reduce a lot of pain for them.

A variety of instruments developed using biosensing technology are also available, but there are many technologies that need to be studied in depth. Medical sensors for diagnosing various diseases have yet to be developed. For example, glutamate sensor is a stable dehydrogenase, transaminase, and blood ammonia indicator. It can replace photometry in many clinical and emergency situations. The measurement has potential application prospects; biosensors for measuring lactic acid index in patients with thoracic surgery have also begun to be applied, and several biosensors combined with renal dialysis have industrial development value. In the future, these biosensors will gradually become popular, bringing more gospel to the majority of patients.

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