Release date: 2015-08-27 According to the US Centers for Disease Control and Prevention, seasonal flu in the US alone results in more than 200,000 hospitalizations and 36,000 deaths per year. Although the annual flu shot provides some protection, the rapid spread of new subtypes beyond the scope of vaccine defense often makes ordinary people feel helpless in a short period of time. The indiscriminate spread of the H1N1 flu (A stream) in 2009 caused approximately 151,700 to 575,400 deaths worldwide. Even though the flu vaccine has been in existence for more than 70 years, because the flu virus has been mutating, there is currently no continuous flu vaccine on the market. However, scientists have been fighting for this great goal. Need a better flu vaccine In the past decade, Scripps Research, Jensen Pharmaceuticals, and other research institutes have found that some patients infected with influenza produce a "strong antibody" that can neutralize at the same time and at the same time. A subtype of influenza virus. Unfortunately, this broadly neutralizing antibody (bnAbs) is very rare. However, the presence of this tempting antibody has attracted the attention of researchers. The Scripps Research Institute and Jensen Pharmaceuticals have begun to work together to develop a specially designed universal flu vaccine. . The researchers aimed at a possible target: hemagglutinin (HA), a protein on the surface of the flu virus. The naming pattern for influenza viruses is "HnNm", where H stands for hemagglutinin protein, n stands for hemagglutinin morphology, and there are 18 species; N stands for another protein: neuraminidase. Hemagglutinin is immunogenic and acts as a "switch" for the virus to invade the host cell, triggering the immune system response, and neutralizing the influenza virus after synthesizing the antibody. The stem of HA is responsible for the connection of cells and viruses, and the structure of the stem of the HA protein of each subtype virus is very small. Once the gene mutation in the stem of the HA occurs, the virus cannot enter the host cell. Therefore, antibodies produced by using the stem of HA as an antigen are expected to neutralize many types of influenza viruses. Neutralizing various subtype influenza viruses In order to achieve this expectation, antibodies to neutralize HA have been developed, and the research community has analyzed the structure of antigens by electron microscopy imaging techniques and X-ray crystallography, especially the antigenic structure matched by CR9114 antibody. For the first time, the researchers used the HA crystal structure to synthesize antigens: the HA protein head structure was removed, the conformation of the protein was stabilized, and the neutralization site was highly mimicked. The artificially modified HA stem is capable of inducing the expected perfect binding of the antibody. This research is a major breakthrough in the development of influenza vaccines. It indicates that the research and development of generic influenza vaccines is in the right direction. The relevant research results were published online in August 24th. Subsequently, scientists used rodents and primates as subjects to test the reaction of antibodies to antigens. They found that after infection with a type of antigen, the animal's immune system secretes antibodies that recognize and bind to the hemagglutinin proteins of many subtypes, even neutralizing H5N1 viruses, and ultimately neutralize the virus. . This is the key evidence. Tests have shown that antibodies produced by a subtype of virus are resistant to antigens of other different subtypes. The ultimate goal of the research team is to include a modified HA stem in the vaccine that induces the synthesis of antibodies against the influenza virus in the body, stimulating them against various subtypes of influenza. Ian Wilson, professor of structural biology at TSRI's Department of Integrated Structural and Computational Biology, said the next step is to validate the clinical effects of the antigen. Distance, the ultimate goal of developing a universal vaccine, there is still a lot of work to be done. Source: Bio-Exploration
Digital Radiography made affordable, Created to meet the needs of community to hospitals and private radiology practices, it enables the price-sensitive customers to join the drive to go digital.The versatile floor mounted radiography system enables you to go from film to CR to DR. Flooe-mounted easy for installation and operation.
United-imaging according to the international advanced processing mode and standardlize design. the parts are made with precision CNC machine and moulding. Which adopt high degree of standardized, reasonable and compact structure. With reliable, durable and elegant appearance and advanced processing technology.
X-Ray Digital Machine,X-Ray Digital Machine In Medical,X-Rays Digital Medical Machine,Medical X-Ray Digital Imaging Machine Shanghai Rocatti Biotechnology Co.,Ltd , https://www.ljdmedical.com
The United-imaging is floor mounted system comprises a radiographic table with integral floor guide rail and a wallstabd. Requiring little room preparation, it is easy to install.
