Release date: 2014-09-19 According to a study published in the September 17 issue of Nature, statins may help bone growth in people with dwarfism (also known as short stature) due to FGFR3 mutations. The researchers differentiated induced stem cells (iPSCs) derived from patient skin cells into chondrocytes, which used them to identify the growth-promoting properties of cholesterol-lowering drugs during drug screening. These patients have the most common form of dwarfism: arrhythmia (achondroplasi), and a rare form of disease called type 1 lethal hypoplasia (TD1). The co-author of the paper, Noriyuki Tsumaki of Kyoto University in Japan, said that obtaining chondrocytes from patients is an invasive process, and few people do so. This makes it difficult to assess the function of FGFR3 mutations in human cells and how they should be treated in patients with these abnormalities. Tsumaki said: "The beauty of iPS cells is that they can take advantage of all cell types from patients, including cells that do not require invasive manipulation. These cells are then reprogrammed into chondrocytes and expanded in large quantities to the cells needed for the study. Quantity." Elvire Gouze of the French National Institute of Health and Medical Research (INSERM) is engaged in the study of achondroplasia. Gouze said: "They clearly show that the cell model is working. I am interested in using this model in my own research." Andrea Superti-Furga, a pediatrician at the University of Lausanne in Switzerland who studies genetic bone disease, said: "This study provides excellent proof that statins may improve... mutation FGFR3 super signal. But then, this article Many questions have also been raised." The researchers used a set of previously derived instructions to generate iPSCs from skin cells and then differentiated them into chondrocytes, the first to construct a specific stem cell line from three patients with echangiogenesis in three TD1 patients. . They also constructed chondrocytes from healthy human skin cells. These chondrocytes form a cell mass inside the cartilage. Cartilage from healthy cells appeared normal, while cartilage from mutant cells failed to develop normally, and tests showed a low level of cartilage marker expression. Currently, there is no specific treatment for achondroplasia or TD1 in addition to a compound C-type natriuretic peptide entering the type 2 clinical trial for achondroplasia treatment. The researchers decided to screen some drugs for drugs that would save chondrocytes to produce cartilage. They found that CNP and statins allow cells to produce cartilage that is less degraded. Previous studies have demonstrated that statins can promote bone growth in rodents. Tsumaki said that the exact mechanism by which statins stimulate proper chondrogenesis remains unclear. Interestingly, his team found that levels of FGFR3 protein, but not FGFR3 mRNA, were reduced in statin-treated cells, suggesting that the drug accelerated the degradation of this protein. Previous research has shown that FGFR3 is a signaling molecule localized in the chondrocyte membrane. The FGFR3 mutation is a function-acquired mutation in achondroplasia and TD1, which means that the mutant protein actively interferes with some cellular processes. The researchers believe that statins may only increase cartilage by inhibiting the over-expressed mutant FGFR3. Next, the team evaluated the effects of statins in mice bearing a carcinogenic dysplasia-causing FGFR3 mutation and found that some animals had longer bone growth in the case of this drug. However, there are still many questions that must be answered between the use of statins in human short stature children. According to Laurence Legeai-Mallet of INSERM, bone growth observed in mice is not significant. “This is a very mild phenotype and they have not observed a powerful effect.†Gouze said that the size of wild-type and mutant mice differed: the smallest mutant mice in this study were larger than the smallest wild-type mice. It is unclear whether it is safe to use statins in children. Because some symptoms of TD1 and achondroplasia appear before birth, it is possible to give children statins as soon as possible or as needed. Although the study confirms that statins are safe for adults and can be used in older children with cholesterol disorders, there is no data to show that it is safe for babies. It is worth noting that cholesterol itself is the key to establishing cell membranes and is especially important for the development of brains in developing children. "Before entering clinical trials, the safety and efficacy of statins for FGFR3 achondroplasia should be extensively tested in animal models," Tsumaki said. Superti-Furga also cautioned: "Many things that work in mice are not necessarily useful in humans." "Despite this, the use of statins to treat patients with FGFR3 mutations still has very exciting prospects and must be prioritized," Superti-Furga said. Source: Biopass
Rhodiola extract is the root extract of Rhodiola, which is sweet and bitter. The main ingredients are salidroside, tyrosol and losevin, which have the effects of enhancing immune function, protecting cardiovascular and cerebrovascular system, anticancer and antidepressant. Rhodiola extract is a natural extract extracted from Rhodiola crenulata, which is refined, concentrated and dried. It is very soluble in water, methanol, ethanol and ether. It is stable to heat. Rhodiola mainly contains phenylpropanoids and flavonoids. Its unique active chemical constituents are phenylpropyl esters, rosavin (the most active), rosin, rosarin, rhodiolin, salidroside and its aglycone [1], namely p-tyrosol. Only Rhodiola rosea contains rosavin, rosin and rosarin.
Product Name: Rhodiola Rosea Extract
Other name : Rhodiola crenulata
Used Part: Root
Specification: 5%
Appearance: Red brown powder
Active Ingredient: Rosavin, salidroside
Test Method: HPLC
Extraction type: Liquid-Solid Extraction
Shelf life: 2 years
Rhodiola rosea is a remarkable herb that has a wide and varied history of uses. It is thought to strengthen the nervous system, fight depression, enhance immunity, elevate the capacity for exercise, enhance memory, aid weight reduction, increase sexual function and improve energy levels. It has long been known as a potent adaptogen. Adaptogens are substances that increase the body's overall resistance and help to normalise bodily functions.
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Recently, a study published in the journal Nature found that statins may help bone growth in people with dwarfism (also known as short stature) due to FGFR3 mutations.
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