Release date: 2016-06-29 The bones on the scaffold are cultured in a bioreactor, which keeps the bone under mechanical stress, ensuring that the bones are the same as the bones in the body. The bone is ready for transplantation in a few weeks. Now, "recovering face" has a new meaning. Active bone cultured using stem cells found in fat can be used to repair a damaged face due to accident or surgery. This is the first time scientists have planted large bones in the laboratory and later transplanted them into pigs to repair the pig's chin. The researchers said that the transplant can accurately replicate the anatomy of the facial bones, which means that facial features can be repaired. This means that people who have suffered accidents or have bone defects can repair their faces with this technique. Dr. Gordana Vunjak-Novakovic of Columbia University said: "This is a big demand, especially for congenital defects, trauma, and people who need bone repair after cancer surgery. So this is a very important step for regenerative medicine. We hope to conduct clinical trials within a few years." The study, published in Science Translational Medicine, transplanted bones cultured in bioreactors into 14 yucatan piglets. For the first time, they used CT scans to create a 3D model of the piglet's jaw, and then they modeled a piece of beef bone and stripped the cells of the bone. This leaves only one stent, and the researchers placed the stem cells extracted from the pig fat on the stent. This stent is then placed in a bioreactor where stem cells can grow and produce bones and blood vessels on this stent. The bones are also affected by the load in the reactor to simulate the pressure in the body. This allows the bone to grow in a more natural way and gives it a certain strength. This living skeleton can be used for transplantation in a few weeks. Scientists used the stem cells extracted from fat to grow bones in the laboratory. They can produce healthy mineralized matrices and strong blood vessels, which are then transplanted into the pig's body to repair the pig's chin. After a few hours, the pig can eat. Dr. Vunjak-Novakovic said that after a few hours of surgery, the pigs can eat. Over time, this lab bone is replaced by new bones formed in the body. Vunjak-Novakovic added: "The role of the bones we cultivate in the laboratory is to 'guide' the template, which is the active bone reconstruction, not the final implant. This property determines that the bone we transplant will become a patient. Part of the bone that allows it to actively adapt to changes in the body." Vunjak-Novakovic and her team are working on new ways to help repair more complex parts of the head and face. They have established a company called epiBone and are planning a human clinical trial. As shown in the animation above, the bone scaffold is placed in a biological reaction window and subjected to a certain tension. The scaffold for placing stem cells is made using bovine bone stripped of cells. Vunjak-Novakovic added: "The quality of this regenerative tissue exceeds that of tissue generated using other methods. Tissue engineering has changed our approach to tissue repair, drug testing, and disease modeling. In all of these different areas, we can Use cells to serve us and generate tissue by providing a bioengineered environment that mimics the natural environment." Source: China Biotechnology Network Cosmetics are compound mixtures made from various raw materials after reasonable blending and processing. There are many types of cosmetics raw materials with different properties. According to the raw material properties and uses of cosmetics, it can be roughly divided into two categories: base raw materials and auxiliary raw materials. The former is a main raw material of cosmetics, which occupies a large proportion in cosmetic formulations, and is the main functional substance in cosmetics. The latter is responsible for shaping, stabilizing or imparting color, fragrance and other characteristics to cosmetics. These substances are not used in large amounts in cosmetic formulations, but are extremely important. Cosmetics are chemical mixtures made of natural, synthetic or extracted substances with different functions as raw materials and processed through production processes such as heating, stirring and emulsification. Collagen peptide, Arbutin, Coenzyme Q10, GSH, Cosmetic Raw Materials, lipoic acid Xi'an Gawen Biotechnology Co., Ltd , https://www.ahualyn-bios.com