The lungs are the respiratory organs of the human body and are essential for gas exchange and protection against pathogen invasion. Once the lungs are damaged, the normal life activities of the human body will also be affected. A recent study by the Zhou Bin Research Group of the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences confirmed that there is a lung pluripotent stem cell involved in lung regeneration in the human body, which can “differentiate on demand†and complete “cross-border maintenance†inside the lung. Related results were published in the international academic journal Nature and Genetics on February 19. Studies have shown that when lung tissue is damaged, a variety of lung bronchial epithelial cells and alveolar epithelial cells will proliferate and differentiate in large quantities, replacing the damaged and dead cells to maintain the normal operation of lung respiratory function. They are powerful, but they are only "specialized" in one area: epithelial cells in different locations are only responsible for maintaining and repairing the epithelial layers of their respective areas. In recent years, scientists have proposed a new type of lung pluripotent stem cells, bronchoalveolar stem cells (BASCs), which are located at the junction of the small bronchi and alveolar cells, and possess molecular features of bronchial epithelial rod cells and type II alveolar epithelial cells. But whether this group of cells actually exist in the body and whether it has the potential to differentiate has been controversial. Zhou Bin's research group used a novel dual homologous recombination labeling technique to achieve specific labeling and tracing of BASCs in experimental mice, demonstrating that BASCs do exist, and found that under normal conditions, BASCs can achieve self-renewal slowly. Maintain lung function. The researchers also found through a series of experiments that BASCs have "cross-border" multi-directional differentiation potential in different injury models. When the lungs and bronchi are damaged by drugs, BASCs can proliferate and differentiate into bronchial epithelial rod cells and ciliated cells. When the alveoli are damaged by drugs, the BASCs can proliferate and differentiate into type I and type II alveolar epithelial cells, thereby restoring the lungs. Features. This study provides new ideas for lung injury repair and regenerative medicine research, and provides a solid theoretical basis for stem cell treatment of lung diseases. (Reporter Wang Chun) Source: Technology Daily Canned Pineapple Chunk In Syrup Canned Pineapple Chunk In Syrup,Pineapple Chunk In Syrup Canned,Pineapple Chunk Canned,Pineapple Chunk Tin ZHANGZHOU TAN CO. LTD. , https://www.zztancan.com
:2019-02-21