Ibrutinib is a small molecule drug that binds permanently to a protein, Bruton's tyrosine kinase (BTK) that is important in B cells; the drug is used to treat B cell cancers like mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenstrom's macroglobulinemia, a form of non-Hodgkin's lymphoma.
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Select a large breeder farm with good reputation and quality assurance; ask the old farmers about the situation of chickens and ask if there is an anal phenomenon, and do not buy chickens without quality assurance.
2 Restrict breeding for broiler chickens and strictly control growth standards
7 Crude protein in the diet of a 14-week-old hen is about 16%. Its purpose is to ensure that the muscle is fully developed, and thereafter it is reduced by 1% every week. By 18 weeks of age, the crude protein in the diet is reduced to 12%. During this period, diets containing metabolisable energy levels should not exceed 2700 kcal/female; diets should be limited to 10% to 20% daily (ie, 80% to 90% of free feed intake); from 7 weeks of age, chickens should be sampled weekly Group 1% to 5% of the chicken body weight, according to the difference between the actual weight and the standard weight to adjust the dietary amount. If the weight exceeds or falls below 1 % of the standard body weight, a corresponding reduction or increase in the amount of feed by 1 % is required next week. Also pay attention to the broiler's movement. Whether it is ground litter brooding or large cage brooding, the optimum time for laying laying hen cages is 17-18 weeks, which can control the broiler chickens to be put into production in proper period and maintain good body condition. To prevent excessive fat, thereby reducing the incidence of dystocia off dystocia.
3 Do a good job of lighting control
Illumination has a great effect on the development of gonads, feeding, nutrient absorption, and egg production. Before 20 weeks of age, the daily illumination time should not exceed 12 to 13 hours. From 20 weeks of age, the daily illumination time starts to increase gradually. Generally, it can be increased by 0.5 to 1 hour per week until it is increased to the daily illumination time of 16 hours. Stable, should not be long or short. If you use automatic light control equipment, be sure to test it before use. The light intensity is 2 to 3W/m for broilers and 3 to 4W/m for laying hens. It is advised to place light sources on both sides of the cage and avoid leaving dead corners.
4 Strengthen feeding and management during the laying period
4.1 After laying hens enter the production peak, not only the egg production rate is high, but the body weight is still increasing, so we should pay attention to the supply of nutrients, according to the egg production level of chickens to a reasonable preparation of the diet, so as not to cause the production of layer hens , defecation, rectal prolapse. In general, in the rising stage of egg production, the amount of protein, vitamins, minerals, and energy should be increased. Once the peak period is reached, it is not necessary to maintain a high level of protein, but sufficient vitamin A, vitamin E, and vitamin D must be provided.
4 . 2 can add 1% to the feed. Methionine or 1.5% gypsum powder prevents prolapse.
4.3 Add sufficient amount of drum skin in the feed, generally adding 2% to 4%, can also better prevent and treat rectal prolapse.
5 Doing day-to-day management
6.1 After the chicken was hatched, it was cut off with an electric heating device or a soldering iron at 6-9 days old. The upper jaw was cut off 1/2 and the lower jaw was cut off 1/3. It was repaired before or at the time of production. Hey, you need to keep the upper jaw short, the lower jaw long, and the rounded ones.
5.2. To reduce and eliminate various factors that can cause stress stimuli in the outside world and prevent frightening chickens from causing frightening groups, chickens with fleas should be kept alone or eliminated.
5.3 Timely prevention of diseases such as E. coli and Salmonella that are likely to cause salpingitis; do a good job of immunization to prevent the occurrence of major diseases.
5.4 Once the anaesthetic chickens are found, they must be immediately isolated. The severe chickens are generally unhealthy and have no therapeutic value and should be disposed of. For chickens with milder symptoms, use 1% potassium permanganate solution or light salt water to wash out the prolapsed part, then apply gentian violet, apply anti-inflammatory powder or terramycin powder, and rub it by hand to reset, but generally not effectively.
Ibrutinib is used to treat chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia, and as a second-line treatment for mantle cell lymphoma, and marginal zone lymphoma.
We produce a series of complete intermediates for Ibrutinib, intermediate I (CAS No. 330786-24-8) and intermediate II (CAS No. 143900-44-1) etc.
All of our products are with stable production and strict quality control, making sure your experience with Sunshine Biotech is always enriching, satisfying and fulfilling.
l Choose high quality chicks