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Controlling the sex of fish is an effective way to increase fish production. The use of sex hormones in general can induce the gender of fish to develop in the direction that people want. There are two types of sex hormones: male sex hormones secreted by the testes and female sex hormones secreted by the ovaries. The primordial reproductive epithelium of fish has both components of the medulla defining the development of the female and the development of the male. Under the action of estrogen, the cortex is partially oxidized into the ovary, and the medulla is not developed but the female is female with egg-laying reproductive function; conversely, under the action of androgens, the fish become male. Therefore, in the course of developing fishery production, if females are to increase the number of fish such as salmon and squid, estrogens can be used to treat them. That is, when the fish are started to feed, the feed is added with a certain amount of benzoic acid. The diol can be treated continuously for two to three months. The proportion of females can reach about 95%. Treated fish have a single sex, a fixed density, not only rapid growth, but also low cost, generally can increase production by about 30%.