Beauty Research: High-fat and high-sugar diet may affect breast cancer treatment January 02, 2019 Source: Xinhuanet As we all know, high-fat and high-sugar foods have many hazards and even increase the risk of cancer. Now, a new study in the United States has found that high-fat and high-sugar foods can lead to elevated levels of glycosylation end products (AGEs) in the body, affecting the treatment of some breast cancer patients. The accumulation of glycosylation end products in the body is the result of the breakdown of nutrients, sugars and fats, which is an unavoidable natural process. It has previously been discovered that aggregation of glycosylation end products may be associated with a range of diseases including diabetes, Alzheimer's disease, cardiovascular disease and the like. Researchers at the University of South Carolina Medical University have found that processed foods rich in fats and sugars or foods cooked by grilling, frying, and frying will increase the level of glycosylation end products in the body. In patients with estrogen receptor-positive breast cancer, elevated levels of glycosylation end products in the body affect the therapeutic effects of tamoxifen. Tamoxifen is an estrogen receptor modulator and a commonly used drug for the treatment of this type of breast cancer. Experiments using breast cancer cell line models have shown that glycation end products increase phosphorylation of estrogen receptor alpha, thereby continuously activating pathways that promote breast cancer cell growth. The addition of tamoxifen will inhibit the growth of these cancer cells, but the addition of a glycosylation end product will cause the cancer cells to grow again. This means that tamoxifen may not be as effective in treating estrogen receptor-positive breast cancer patients with high levels of glycosylation end products. Related papers have been published in the academic journal Breast Cancer Research and Therapy. David Turner, an assistant professor at the University of South Carolina Medical School who led the research, said the study revealed the effects of diet-related glycation end products on the efficacy of breast cancer therapy, which may lead to lifestyle interventions for patients. Try to avoid an increase in the level of glycosylation end products in their bodies. Celery Extract Apigenin,Marigold Flower Extract,Plant Extract Ursolic Acid Shaanxi HuiKe Botanical Development Co.,Ltd , https://www.oasis-hk.com