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Recently, a research report published in the international magazine Nature Communications, scientists from the University of Pennsylvania's Perelman School of Medicine developed a new drug transport technology that can be used Red blood cells are used to transport nano drug carriers (RBC-hitchhiking, red blood cell free-riding technology). After using animal models, researchers have found that this technology can significantly increase the concentration of drugs delivered to selected organs, and related research or you can help improve treatment. Drug delivery technologies for diseases such as acute lung disease, stroke and heart attack.
Researcher Jake Brenner said that most drugs are currently ineffective because they spread throughout the body and when they reach nearby organs, they cause side effects that are unacceptable to the patient. However, these drugs may not reach the affected area directly. . By increasing the concentration of drugs that reach specific tissue sites, the "red cell free-riding technology" developed by researchers can reduce the potential side effects of drugs and improve the efficiency of drug delivery to targeted organs.
Researchers say the new drug delivery technology can accurately deliver nanoscale drug carriers to selected organs by orienting intravascular catheters in the lungs of mice, pigs, and humans, while not Causes toxic effects of red blood cells or organs. Because of their biocompatibility, red blood cells are a very attractive transport vehicle, and they have been trying to find ways to conduct clinical trials in the years when researchers started this work.
The researchers found that this special drug delivery vehicle can increase the absorption of the drug in the lung by about 40 times compared to the free circulating drug carrier absorbed in the blood. In addition, the new drug is added. The transport carrier implants the carotid artery and can inject 10% of the drug into the brain. This method is 10 times more efficient than the previous method, such as using antibodies to direct the drug into a pre-target. When applied to the brain, such a new drug delivery technology can be used to treat brain diseases such as acute stroke.
The development of this new "red cell free-riding technology" is of great significance for future clinical applications. The maximum surface area of ​​interaction between cells and cells is more than that of red blood cells and vascular wall cells, so researchers firmly believe that this New drug delivery technologies may or will improve the treatment of a variety of human diseases in the future.
Original source: Brenner JS, Pan DC, Myerson JW, et al. Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude. Nat Commun. 2018 Jul 11;9(1):2684. doi: 10.1038/ S41467-018-05079-7