New research says that triple therapy is effective in treating high blood pressure August 24, 2018 Source: Xinhua News Agency Author: Zhou Zhou A study published in the Journal of the American Medical Association showed that the combination of three antihypertensive drugs in patients with hypertension can improve the effectiveness of treatment, while also ensuring safety. This study is expected to change the way in which antihypertensive drugs are administered. The new administration method uses three drugs, telmisartan, amlodipine and chlorthalidone, each of which is dose-reduced in a conventional manner, and they are placed in one capsule. Conventional therapies usually start with a small dose of a single drug and consider increasing the dose or giving a new drug based on blood pressure control. An international team of researchers from Australia, Sri Lanka and other countries reported that 700 hypertensive patients were recruited from 11 hospitals and clinics in Sri Lanka. They were randomly divided into two groups. About half of them used triple therapy and took one capsule a day. Containing 20 mg of telmisartan, 2.5 mg of amlodipine and 12.5 mg of chlorthalidone, the other half used conventional therapy. Clinical trials have shown that after half a year, 70% of hypertensive patients with triple therapy achieve blood pressure control goals, compared with 55% in conventional therapy patients. In the proportion of side effects such as muscle pain, joint pain, and dizziness, the patients who used triple therapy were similar to those who used conventional therapy, and there was no significant difference in the proportion of patients who discontinued the drug due to side effects. One of the authors, Ruth Webster of the University of New South Wales in Australia, said that patients with hypertension should be reviewed frequently to adjust their medications and dosages. This is time-consuming and laborious, and many doctors and patients are afraid of trouble and not complying with the norms. The method of triple administration is simpler and more effective than conventional therapy.
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