Release date: 2017-09-18 A physiological paper published in the British journal Nature Communications recently stated that the age of the uterus affects the embryo transfer and pregnancy success rate in mice. Previous studies have focused on how egg cell defects lead to age-related pregnancy complications, but new findings underscore that the maternal environment is also an important contributor to pregnancy complications. Scientists have previously known that the age of pregnant women will greatly increase the risk of reproduction, and the ageing of egg cells may lead to chromosomal defects in the embryo and further trigger the termination of early pregnancy. This time, the scientist of the British Institute of Babrahan, Merialm Hanberg, and his colleagues, through studying mice, proposed another possible cause of pregnancy complications in late pregnancy. They observed that the older the mother, the lower the fetal health and survival rate. Health problems that arise include stunting and heart defects, which are associated with defects in the placenta that provide nutrients to the embryo in the uterus. Team studies have shown that these problems can be solved by transferring embryos from an older mother to a young recipient. Experiments have shown that the ability of the uterus to support placenta and embryos decreases with age. Uterine aging is associated with a decrease in the number of immune cells in the decidua, a structure in the uterus that supports the growth and development of the embryo together with the placenta. They also found that as the age increases, the hormones in the uterus stimulate the formation of decidua. These results emphasize that the age of the mouse's mother may affect embryo survival - not just the age of the egg cells, but also the age of the uterus. However, the study is currently limited to mice and there is no evidence that this mechanism exists in humans. Source: Technology Daily
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