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A research team led by the scientist of the iPS Cell Research Institute at Kyoto University in Japan, using iPS cells (human induced pluripotent stem cells), successfully produced the three-dimensional structure of the renal tubule, an important organ in the kidney. So far, people have successfully produced retinal cells and cardiomyocytes using iPS cells, and it is the first time to make complex internal organ structures.
According to reports, the researchers first injected specific enzymes into iPS cells, which can efficiently produce intermediate mesoderm tissue, which is the mesoderm located between the paraventricular mesoderm and the mesoderm. Tissue can differentiate into the main organs of the genitourinary system. Then, they mix the kidney cells taken out from the rat embryo with the intermediate interstitial tissue, which eventually grows into a tissue having a tubular structure. The researchers analyzed the composition of this tissue and determined that it contained specific proteins in human renal tubules. This result shows that stereoscopic kidney organs can be produced using iPS cells.
The researchers said that although the study is still in the experimental stage, there is still a long way to go before using iPS cells to make a formal internal organ, but it is an important first step. The results of this research are expected to help patients with renal dysfunction and other kidney diseases to be completely cured in the future.
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